TIVOXEN 1.34 MG (Tivozanib )

Basic Product Information of Tivoxen (Tivozanib) 1.34mg

How Tivoxen (Tivozanib) Works

Tivoxen contains Tivozanib, an oral, next-generation inhibitor of the vascular endothelial growth factor receptor (VEGFR) family. The VEGF signalling pathway plays a central role in tumour angiogenesis, the process by which cancers form the new blood vessels they need to grow and spread, and VEGFR tyrosine kinase inhibitors are an established class of treatment for renal cell carcinoma.

Tivozanib acts as a potent, selective inhibitor of VEGFR-1, VEGFR-2, and VEGFR-3, and, at clinically relevant concentrations, also inhibits c-KIT and PDGFR-beta. With a comparatively long half-life, Tivozanib was designed to optimise VEGF pathway blockade while aiming for improved tolerability relative to some earlier VEGFR-targeted therapies. In pre-clinical tumour models, Tivozanib inhibited angiogenesis, vascular permeability, and tumour growth, and in the pivotal TIVO-3 clinical trial, it was associated with longer progression-free survival compared with sorafenib in patients with relapsed or refractory advanced RCC.

Tivoxen is taken as an oral capsule, using a distinctive 21 days on treatment, followed by 7 days off schedule, repeated in 28-day cycles.

Indication for Tivoxen (Tivozanib)

Tivoxen (Tivozanib) is indicated for the following condition:

Benefits of Tivoxen (Tivozanib) 1.34mg

How to Take Tivoxen (Tivozanib)

Monitoring and Dosage Adjustments

Regular monitoring is essential throughout Tivoxen treatment. Your oncologist will monitor blood pressure closely, particularly during the first cycle, given the high frequency of hypertension with this medicine, along with cardiac function in patients with cardiac risk factors. Monitoring also includes assessment for signs of bleeding, urine protein (proteinuria), and thyroid function, since hypothyroidism is a recognised side effect. Wound healing is also assessed before any planned surgery, as treatment is typically interrupted beforehand. Report any severe headache, chest pain, breathlessness, unusual bleeding or bruising, severe abdominal pain, vision changes, confusion, or seizures to your doctor immediately.

Drug Interactions and Important Information

Use with caution alongside other medicines known to raise blood pressure or that affect blood clotting, and inform your physician of any history of cardiovascular disease, thromboembolic events, or bleeding disorders before starting treatment. Surgery or invasive procedures, including dental surgery, should be planned around Tivoxen treatment, as it may impair wound healing; contact your healthcare provider before any planned surgery.

Tivoxen can cause foetal harm and may impair fertility in both men and women. Women of childbearing potential and men with partners of childbearing potential should use effective contraception during treatment and for a period after the final dose, as advised by their physician. Always inform your physician of all medications, supplements, and herbal products you are currently taking before starting Tivoxen.

Side Effects and Precautions

Who Should Use Tivoxen (Tivozanib)?

Tivoxen is suitable for adult patients with relapsed or refractory advanced Renal Cell Carcinoma who have already received two or more prior systemic therapies, including patients who have progressed on earlier VEGFR-targeted treatment. It is prescribed by medical oncologists experienced in managing later-line RCC therapy and its associated cardiovascular risks. A thorough medical assessment including blood pressure, cardiac risk evaluation, thyroid function, and bleeding risk is required before initiating treatment.

Manufacturer: Everest Pharmaceuticals Ltd.

Everest Pharmaceuticals Ltd. is a vertically integrated pharmaceutical company based in Dhaka, Bangladesh, focused on complex, technology-driven specialty medicines across oncology, nephrology, and virology. Operating under Bangladesh’s TRIPS/Doha Declaration exemption for least-developed countries, Everest manufactures advanced generics such as Tivoxen under cGMP-compliant standards, with the stated mission of making high-cost, life-saving medicines accessible and affordable to patients around the world. Tivoxen is one of Everest’s specialty oncology products, offering a bioequivalent alternative to Fotivda by AVEO Pharmaceuticals at a fraction of the cost.

Global Supplier: Mediaid Pharmacy with Worldwide Shipping

Mediaid Pharmacy is a trusted global supplier of specialty and oncology medications. We ensure Tivoxen (Tivozanib) is accessible to patients and healthcare providers worldwide through reliable worldwide shipping. Whether you are located in South Asia, the Middle East, Africa, Europe, or beyond, Mediaid Pharmacy provides fast and reliable delivery with full order support. Contact us directly via WhatsApp, phone, or WeChat for pricing, availability, and delivery enquiries.

Why Choose Tivoxen (Tivozanib) from Mediaid Pharmacy?

Tivoxen represents an important later-line option for patients with relapsed or refractory advanced kidney cancer. As the generic equivalent of Fotivda by AVEO Pharmaceuticals, it delivers the same active ingredient, Tivozanib, with the same proven, selective VEGFR-inhibition mechanism at a dramatically more affordable price. Manufactured by Everest Pharmaceuticals Ltd. under cGMP-compliant standards and distributed globally by Mediaid Pharmacy, Tivoxen gives patients worldwide access to advanced targeted kidney cancer therapy without the financial burden of brand-name alternatives. For patients and physicians seeking a proven, affordable, and accessible Tivozanib option with worldwide delivery, Tivoxen from Mediaid Pharmacy is the trusted choice.

Frequently Asked Questions About Tivoxen (Tivozanib)