Caboxen 20 MG And 80 MG (Cabozantinib)
Product Name : Caboxen
Generic Name : Cabozantinib
Formulation : Capsule
Available Pack Size : 30’s & 90’s
Available Strengths : 20 mg and 80 mg
Registrations : Bangladesh
Product Information
Caboxen (Cabozantinib) 20mg and 80mg is an oral multi-targeted receptor tyrosine kinase inhibitor used for the treatment of progressive, metastatic Medullary Thyroid Cancer (MTC) in adults. It works by inhibiting the tyrosine kinase activity of MET, VEGFR-1, -2, and -3, RET, AXL, and other receptors involved in tumour angiogenesis, oncogenesis, and metastasis, cutting off the growth and spread signals that MTC tumour cells depend on. Manufactured by Everest Pharmaceuticals Ltd., Bangladesh and globally supplied by Mediaid Pharmacy with worldwide shipping.
Basic Product Information of Caboxen (Cabozantinib) 20mg and 80mg
| Brand Name | Caboxen (Cabozantinib) |
| Generic Name | Cabozantinib (as Cabozantinib (S)-Malate) INN |
| Drug Class | Multi-Targeted Receptor Tyrosine Kinase Inhibitor |
| Available Strengths | 20mg and 80mg |
| Formulation | Capsule (Not Interchangeable with Cabozantinib Tablets) |
| Pack Size | 20mg: 90 Capsules per Bottle. 80mg: 30 Capsules per Bottle. |
| Primary Indication | Progressive, Metastatic Medullary Thyroid Cancer (MTC) |
| Regulatory Approvals | USFDA Approved (Medullary Thyroid Cancer). EMA Approved. |
| Originator Brand | Cometriq by Exelixis |
| Manufacturer | Everest Pharmaceuticals Ltd., Dhaka, Bangladesh |
| Global Supplier | Mediaid Pharmacy, Worldwide Shipping Available |
| Registration | Registered in Bangladesh |
| Storage Conditions | Store below 30 degrees Celsius. Keep in a dry place away from light and moisture. Keep out of the reach of children. |
How Caboxen (Cabozantinib) Works
Caboxen contains Cabozantinib, an inhibitor of multiple receptor tyrosine kinases (RTKs) involved in both normal cellular function and pathological processes such as oncogenesis, tumour angiogenesis, metastasis, drug resistance, and maintenance of the tumour microenvironment. In vitro studies have shown that Cabozantinib inhibits the tyrosine kinase activity of MET, VEGFR-1, -2, and -3, AXL, RET, ROS1, TYRO3, MER, KIT, TRKB, FLT-3, and TIE-2.
In medullary thyroid cancer, the RET receptor tyrosine kinase is frequently mutated or overactive, driving abnormal cell growth. By simultaneously inhibiting RET alongside MET and the VEGFR family, Caboxen blocks the signalling pathways tumour cells rely on to grow, form new blood vessels, and spread, helping to slow or stop disease progression.
Caboxen is a capsule formulation and is not interchangeable with cabozantinib tablets, which are formulated differently, dosed differently, and approved for different cancers. It is taken as a once-daily oral capsule, on an empty stomach, specifically for progressive, metastatic medullary thyroid cancer.
Indication for Caboxen (Cabozantinib)
Caboxen (Cabozantinib) capsules are indicated for the following condition:
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Progressive, Metastatic Medullary Thyroid Cancer (MTC) For the treatment of adult patients with progressive, metastatic medullary thyroid cancer. This capsule formulation of Cabozantinib is indicated specifically for MTC and is not approved, or interchangeable, for use in renal cell carcinoma, hepatocellular carcinoma, or other cancers treated with the separate cabozantinib tablet formulation. |
Benefits of Caboxen (Cabozantinib) 20mg and 80mg
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Dedicated MTC Therapy Caboxen is formulated and dosed specifically for progressive, metastatic medullary thyroid cancer, a rare cancer with few approved targeted treatment options. |
Broad Multikinase Action By targeting RET, MET, VEGFR, and other receptor tyrosine kinases simultaneously, Caboxen addresses multiple pathways that MTC tumours depend on for growth and spread. |
Convenient Once-Daily Dosing Caboxen is taken as a once-daily oral capsule, allowing eligible patients to manage treatment on an outpatient basis rather than through hospital-based infusions. |
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Affordable Alternative to Cometriq Caboxen contains the same active ingredient as Cometriq by Exelixis, at a significantly lower cost, making long-term targeted therapy more financially accessible. |
Dose-Adjustable Regimen The 140mg starting dose can be reduced in defined steps to manage side effects, using the same 20mg and 80mg capsules, allowing many patients to continue therapy at a tolerated dose. |
cGMP Certified Manufacturing Produced by Everest Pharmaceuticals Ltd. under cGMP-compliant manufacturing standards, helping ensure consistent quality, purity, and potency in every batch of Caboxen capsules. |
How to Take Caboxen (Cabozantinib)
Route: Oral. Swallow capsules whole; do not open, crush, or chew them.
Standard dose: 140mg once daily, taken as one 80mg capsule and three 20mg capsules, continued until disease progression or unacceptable toxicity, exactly as directed by the prescribing oncologist.
With food: Do NOT administer with food. Do not eat for at least 2 hours before, and at least 1 hour after, taking Caboxen.
Missed dose: Do not take a missed dose if it is within 12 hours of the next scheduled dose.
Dose reduction for toxicity: For adverse reactions requiring dose reduction, treatment is typically reduced first to 100mg once daily (one 80mg capsule and one 20mg capsule), and if needed, further reduced to 60mg once daily (three 20mg capsules), as directed by the prescribing physician.
Hepatic impairment: The recommended starting dose is 80mg once daily in patients with mild or moderate hepatic impairment. Caboxen has not been studied in severe hepatic impairment.
CYP3A4 interactions: Avoid coadministration with strong CYP3A4 inhibitors and inducers where possible, as these significantly alter Cabozantinib plasma exposure. Do not consume grapefruit, grapefruit juice, or nutritional supplements known to inhibit cytochrome P450 while taking Caboxen.
Formulation note: Do NOT substitute Caboxen capsules with cabozantinib tablets; the two formulations are dosed differently and are not interchangeable.
Paediatric use: The safety and efficacy of Caboxen in children and adolescents have not been established. No data are currently available.
Monitoring and Dosage Adjustments
Regular monitoring is essential throughout Caboxen treatment. Your oncologist will monitor for signs of gastrointestinal perforation or fistula (severe abdominal pain, fever), bleeding, and thrombotic events (chest pain, breathlessness, limb swelling). Monitoring also includes blood pressure, liver function tests, urine protein for signs of kidney involvement, and wound healing before and after any surgical procedure, since treatment is typically interrupted around planned surgery. Report any severe abdominal pain, unusual bleeding, chest pain, sudden breathlessness, severe headache, or signs of infection to your doctor immediately.
Drug Interactions and Important Information
Avoid concomitant use of Caboxen with strong CYP3A4 inhibitors (such as ketoconazole, itraconazole, and clarithromycin), as these can increase Cabozantinib exposure, and strong CYP3A4 inducers (such as rifampicin, carbamazepine, and phenytoin), as chronic co-administration can reduce Cabozantinib exposure and effectiveness. Cabozantinib is also a substrate of MRP2; MRP2 inhibitors have the potential to increase plasma concentrations of Cabozantinib.
Surgery or invasive procedures should be planned around Caboxen treatment, as it may impair wound healing; treatment is typically interrupted before elective surgery and not resumed until adequate wound healing has occurred. Women of childbearing potential should use effective contraception during treatment. Always inform your physician of all medications, supplements, and herbal products you are currently taking before starting Caboxen.
Side Effects and Precautions
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Common Side Effects Diarrhoea Nausea and vomiting Mouth sores and stomach pain Constipation and decreased appetite Fatigue and weakness Weight loss and taste changes Hoarseness and hair colour changes Hand-foot skin reaction |
Serious Warnings and Precautions Gastrointestinal perforation and fistula formation. Discontinue for Grade 4 events. Severe haemorrhage. Arterial and venous thromboembolic events. Hypertension, including hypertensive crisis. Impaired wound healing. Interrupt treatment before planned surgery. Reversible posterior leukoencephalopathy syndrome (RPLS), a rare neurological condition. Embryo-foetal toxicity. Not recommended during pregnancy or breastfeeding. |
Who Should Use Caboxen (Cabozantinib)?
Caboxen is suitable for adult patients diagnosed with progressive, metastatic medullary thyroid cancer. It is prescribed by medical oncologists and endocrine oncology specialists experienced in managing this rare cancer and the associated risks of multikinase inhibitor therapy. A thorough medical assessment including blood pressure, liver function, and screening for bleeding or clotting risk is required before initiating treatment, and treatment is generally planned around any upcoming surgical procedures.
Manufacturer: Everest Pharmaceuticals Ltd.
Everest Pharmaceuticals Ltd. is a vertically integrated pharmaceutical company based in Dhaka, Bangladesh, focused on complex, technology-driven specialty medicines across oncology, nephrology, and virology. Operating under Bangladesh’s TRIPS/Doha Declaration exemption for least-developed countries, Everest manufactures advanced generics such as Caboxen under cGMP-compliant standards, with the stated mission of making high-cost, life-saving medicines accessible and affordable to patients around the world. Caboxen is one of Everest’s specialty oncology products, offering a bioequivalent alternative to Cometriq by Exelixis at a fraction of the cost.
Global Supplier: Mediaid Pharmacy with Worldwide Shipping
Mediaid Pharmacy is a trusted global supplier of specialty and oncology medications. We ensure Caboxen (Cabozantinib) is accessible to patients and healthcare providers worldwide through reliable worldwide shipping. Whether you are located in South Asia, the Middle East, Africa, Europe, or beyond, Mediaid Pharmacy provides fast and reliable delivery with full order support. Contact us directly via WhatsApp, phone, or WeChat for pricing, availability, and delivery enquiries.
Why Choose Caboxen (Cabozantinib) from Mediaid Pharmacy?
Caboxen represents a dedicated, targeted option for patients facing progressive, metastatic medullary thyroid cancer, a rare cancer with limited treatment choices. As the generic equivalent of Cometriq by Exelixis, it delivers the same active ingredient, Cabozantinib, in the same capsule formulation and dosing regimen at a dramatically more affordable price. Manufactured by Everest Pharmaceuticals Ltd. under cGMP-compliant standards and distributed globally by Mediaid Pharmacy, Caboxen gives patients worldwide access to advanced targeted cancer therapy without the financial burden of brand-name alternatives. For patients and physicians seeking a proven, affordable, and accessible Cabozantinib capsule option with worldwide delivery, Caboxen from Mediaid Pharmacy is the trusted choice.
Frequently Asked Questions About Caboxen (Cabozantinib)
What is Caboxen (Cabozantinib) used for?
Caboxen (Cabozantinib) capsules are used to treat adult patients with progressive, metastatic medullary thyroid cancer (MTC). This capsule formulation is specifically approved for MTC; it is not the same product, dose, or indication as the separate cabozantinib tablet formulation used for kidney or liver cancer.
How should I take Caboxen (Cabozantinib)?
Caboxen is taken orally, once daily, on an empty stomach — do not eat for at least 2 hours before and at least 1 hour after your dose. The standard dose is 140mg (one 80mg capsule and three 20mg capsules) once daily. Dose reductions to 100mg or 60mg once daily may be used to manage side effects. Always follow your oncologist’s exact instructions.
What strengths is Caboxen (Cabozantinib) available in?
Caboxen is available in 20mg and 80mg capsules, with the 20mg strength supplied in a bottle of 90 capsules and the 80mg strength supplied in a bottle of 30 capsules. The standard 140mg daily dose is made up using one 80mg capsule plus three 20mg capsules.
Is Caboxen the same as Cometriq (Cabozantinib by Exelixis)?
Yes. Caboxen is the generic equivalent of Cometriq. Both contain the same active ingredient, Cabozantinib, in the same 20mg and 80mg capsule strengths, dosed the same way for medullary thyroid cancer. Caboxen is manufactured by Everest Pharmaceuticals Ltd. in Bangladesh and offers the same clinical mechanism as Cometriq at a significantly lower cost.
What are the side effects of Caboxen (Cabozantinib)?
Common side effects include diarrhoea, nausea, mouth sores, fatigue, weight loss, and hand-foot skin reaction. Serious but less common risks include gastrointestinal perforation or fistula, severe bleeding, blood clots, and high blood pressure. Always consult your oncologist for a complete assessment of your individual risks and benefits before starting treatment.
Can Caboxen be used with other medications?
Caboxen should not be combined with strong CYP3A4 inhibitors or inducers without a physician-directed dose adjustment. Avoid grapefruit products during treatment, and treatment is usually paused before planned surgery due to effects on wound healing. Always inform your physician of all medications, supplements, and herbal products you are taking before starting Caboxen.
Is Caboxen (Cabozantinib) safe during pregnancy or breastfeeding?
No. Caboxen is not recommended during pregnancy or breastfeeding, as it can cause foetal harm. Women of childbearing potential should use effective contraception during treatment, as advised by their physician. Please consult your physician before starting treatment if you are pregnant, planning to become pregnant, or breastfeeding.
Can I order Caboxen (Cabozantinib) online with worldwide shipping?
Yes. Mediaid Pharmacy supplies Caboxen (Cabozantinib) 20mg and 80mg globally with worldwide shipping. Contact us via WhatsApp, phone, or WeChat at +8801773428128 or email us at info@mediaidpharmacy.com to enquire about pricing, availability, and delivery to your country.
Order Caboxen (Cabozantinib) 20mg and 80mg with Worldwide Shipping
Phone / WhatsApp / WeChat: +8801773428128 | Email: info@mediaidpharmacy.com
