Sunitinib 50 MG (Sunitix)
Product Name : Sunitinib (Sunitix)
Generic Name : Sofosbuvir
Formulation : Capsule
Available Pack Size : 1×6’s
Available Strengths : 50 mg
Registrations : Bangladesh, Sri lanka, Nepal
Product Information
Sunitix (Sunitinib) 50mg is an oral multi-targeted receptor tyrosine kinase (RTK) inhibitor used to treat advanced Renal Cell Carcinoma (RCC), Gastrointestinal Stromal Tumour (GIST) after progression on or intolerance to imatinib, and advanced Pancreatic Neuroendocrine Tumours (pNET). It works by simultaneously blocking multiple receptor tyrosine kinases involved in tumour angiogenesis and tumour cell proliferation, reducing the blood supply tumours depend on and triggering cancer cell death. Manufactured by Beacon Pharmaceuticals Ltd., Bangladesh and globally supplied by Mediaid Pharmacy with worldwide shipping.
Basic Product Information of Sunitix (Sunitinib) 50mg
| Brand Name | Sunitix (Sunitinib) |
| Generic Name | Sunitinib (as Sunitinib Malate) INN |
| Drug Class | Multi-Targeted Receptor Tyrosine Kinase (RTK) Inhibitor |
| Available Strength | 50mg |
| Formulation | Capsule |
| Pack Size | 1 x 6 Capsules |
| Primary Indication | Advanced Renal Cell Carcinoma, Gastrointestinal Stromal Tumour, and Pancreatic Neuroendocrine Tumours |
| Regulatory Approvals | USFDA Approved (RCC, GIST, pNET). EMA Approved. |
| Originator Brand | Sutent by Pfizer |
| Manufacturer | Beacon Pharmaceuticals Ltd., Mymensingh, Bangladesh |
| Global Supplier | Mediaid Pharmacy, Worldwide Shipping Available |
| Registration | Registered in Bangladesh, Sri Lanka, and Nepal |
| Storage Conditions | Store below 30 degrees Celsius. Keep in a dry place away from light and moisture. Keep out of the reach of children. |
How Sunitix (Sunitinib) Works
Sunitix contains Sunitinib, an oral inhibitor that targets multiple receptor tyrosine kinases (RTKs) involved in tumour growth, angiogenesis, and metastatic progression. These include all receptors for platelet-derived growth factor (PDGFR-alpha and PDGFR-beta) and vascular endothelial growth factor (VEGFR1, VEGFR2, and VEGFR3), which play a central role in both the formation of new blood vessels that feed tumours and the proliferation of tumour cells themselves.
By simultaneously inhibiting these targets, Sunitinib reduces tumour vascularisation and triggers cancer cell apoptosis, leading to tumour shrinkage. Sunitinib also inhibits CD117 (c-KIT), the receptor tyrosine kinase that, when abnormally activated by mutation, drives the majority of gastrointestinal stromal tumours, as well as additional receptors including RET, CD114, and CD135. This broad receptor profile is also responsible for characteristic side effects such as hand-foot skin reaction and stomatitis.
Because of this multi-target mechanism, Sunitix is classified as a targeted therapy rather than conventional chemotherapy. It is taken as an oral capsule, with the dosing schedule tailored to the specific cancer being treated.
Indications for Sunitix (Sunitinib)
Sunitix (Sunitinib) is indicated for the following conditions:
|
Advanced Renal Cell Carcinoma (RCC) For the treatment of adult patients with advanced renal cell carcinoma (kidney cancer). |
Gastrointestinal Stromal Tumour (GIST) For the treatment of GIST after disease progression on, or intolerance to, imatinib mesylate. |
|
Pancreatic Neuroendocrine Tumours (pNET) For the treatment of progressive, well-differentiated pancreatic neuroendocrine tumours in adult patients with unresectable, locally advanced, or metastatic disease. |
|
Benefits of Sunitix (Sunitinib) 50mg
|
Broad Multi-Cancer Coverage Approved across kidney cancer, GIST, and pancreatic neuroendocrine tumours, Sunitix supports patients across three distinct and difficult-to-treat cancer types. |
Broad Multikinase Action By targeting VEGFR, PDGFR, c-KIT, and other receptor tyrosine kinases simultaneously, Sunitix addresses both tumour angiogenesis and tumour cell proliferation at once. |
Convenient Oral Dosing Sunitix is taken as an oral capsule, with or without food, allowing eligible patients to manage treatment on an outpatient basis rather than through hospital infusions. |
|
Affordable Alternative to Sutent Sunitix contains the same active ingredient as Sutent by Pfizer, at a significantly lower cost, making long-term targeted cancer therapy more financially accessible. |
Second-Line GIST Option For GIST patients who progress on or cannot tolerate imatinib, Sunitix offers a well-established next-line treatment option. |
WHO-GMP and cGMP Certified Produced by Beacon Pharmaceuticals Ltd. under strict WHO-GMP, cGMP, and ISO-certified manufacturing standards, ensuring every batch of Sunitix meets consistent quality, safety, and efficacy requirements. |
How to Take Sunitix (Sunitinib)
Route: Oral, taken with a glass of water. Capsules should be swallowed whole.
Standard dose for GIST and RCC: One 50mg capsule once daily, on a schedule of 4 weeks on treatment followed by 2 weeks off (Schedule 4/2), repeated in 6-week cycles, exactly as directed by the prescribing oncologist.
Dosing for pNET: Pancreatic neuroendocrine tumours are typically treated with a lower dose taken continuously, without a scheduled break, which generally requires a lower-strength capsule; your oncologist will determine and prescribe the appropriate strength and schedule for this indication.
With food: Can be taken with or without food, at approximately the same time each day.
Missed dose: If a dose is missed, do not take an additional capsule; resume the normal schedule with the next planned dose.
Hepatic impairment: No dose adjustment is required in mild or moderate hepatic impairment. Sunitix has not been studied in severe hepatic impairment; use with caution and close monitoring if prescribed.
Renal impairment: No dose adjustment is generally required based on renal function, though patients with severe impairment or on dialysis should be closely monitored.
CYP3A4 interactions: If coadministration with a strong CYP3A4 inhibitor cannot be avoided, a dose reduction to a minimum of 37.5mg (GIST/RCC) or a lower pNET dose should be considered. Strong CYP3A4 inducers, such as rifampicin, may decrease Sunitinib plasma concentrations and should generally be avoided.
Paediatric use: The safety and efficacy of Sunitix in children and adolescents have not been established. No data are currently available.
Monitoring and Dosage Adjustments
Regular monitoring is essential throughout Sunitix treatment. Your oncologist will monitor liver function tests, left ventricular ejection fraction (LVEF) in patients with cardiac risk factors, and ECG for QT prolongation where indicated. Monitoring also includes blood pressure, checked regularly and especially during the first cycle, thyroid function, blood glucose in diabetic patients, complete blood counts, and urine protein for signs of kidney involvement. Report any yellowing of the skin or eyes, chest pain, breathlessness, severe headache, unusual bleeding or bruising, or swelling to your doctor immediately.
Drug Interactions and Important Information
Avoid concomitant use of Sunitix with strong CYP3A4 inhibitors (such as ketoconazole, itraconazole, and clarithromycin) where possible; if coadministration cannot be avoided, dose reduction as directed by the prescribing physician is required. Avoid concomitant use with strong CYP3A4 inducers (such as rifampicin, carbamazepine, and phenytoin), as these reduce Sunitinib effectiveness. Avoid grapefruit and grapefruit juice during treatment.
Use with caution alongside other medicines known to prolong the QTc interval, and inform your physician of any history of cardiac disease, hypertension, thyroid disorders, or diabetes before starting treatment. Women of childbearing potential should use effective contraception during treatment. Always inform your physician of all medications, supplements, and herbal products you are currently taking before starting Sunitix.
Side Effects and Precautions
|
Common Side Effects Fatigue Diarrhoea and nausea Hand-foot skin reaction and rash Stomatitis (mouth sores) and taste changes Hypertension Decreased appetite and weight loss Skin and hair colour changes Bleeding, bruising, and low blood counts |
Serious Warnings and Precautions Hepatotoxicity, including rare cases of fatal liver failure. Cardiac dysfunction, including reduced left ventricular ejection fraction and QT interval prolongation. Serious haemorrhage, including gastrointestinal, respiratory, and tumour-related bleeding. Adrenal and thyroid dysfunction, requiring periodic monitoring. Impaired wound healing. Treatment is typically interrupted before planned surgery. Thrombotic microangiopathy and osteonecrosis of the jaw (rare). Embryo-foetal toxicity. Not recommended during pregnancy or breastfeeding. |
Who Should Use Sunitix (Sunitinib)?
Sunitix is suitable for adult patients diagnosed with advanced Renal Cell Carcinoma, Gastrointestinal Stromal Tumour that has progressed on or is intolerant to imatinib, or progressive, well-differentiated Pancreatic Neuroendocrine Tumours that are unresectable, locally advanced, or metastatic. It is prescribed by medical oncologists experienced in managing multikinase inhibitor therapy and its associated cardiovascular and metabolic risks. A thorough medical assessment including cardiac evaluation, liver and thyroid function, and blood pressure is required before initiating treatment.
Manufacturer: Beacon Pharmaceuticals Ltd.
Beacon Pharmaceuticals Ltd. is a leading pharmaceutical manufacturer based in Mymensingh, Bangladesh, and the number one oncology and specialty medicine company in the country. Beacon is the first company in Bangladesh to export cancer drugs and currently exports to Asia, Africa, Europe, and Latin America. Sunitix is registered for supply in Bangladesh, Sri Lanka, and Nepal, and Beacon operates under strict WHO-GMP, cGMP, and ISO-certified standards, offering an affordable and bioequivalent alternative to Sutent at a fraction of the cost.
Global Supplier: Mediaid Pharmacy with Worldwide Shipping
Mediaid Pharmacy is a trusted global supplier of specialty and oncology medications. We ensure Sunitix (Sunitinib) is accessible to patients and healthcare providers worldwide through reliable worldwide shipping. Whether you are located in South Asia, the Middle East, Africa, Europe, or beyond, Mediaid Pharmacy provides fast and reliable delivery with full order support. Contact us directly via WhatsApp, phone, or WeChat for pricing, availability, and delivery enquiries.
Why Choose Sunitix (Sunitinib) from Mediaid Pharmacy?
Sunitix represents a well-established, versatile option across three distinct cancer types. As the generic equivalent of Sutent by Pfizer, it delivers the same active ingredient, Sunitinib, with the same proven multi-target receptor tyrosine kinase inhibition mechanism at a dramatically more affordable price. Manufactured by the internationally trusted Beacon Pharmaceuticals Ltd. under WHO-GMP and cGMP standards, and distributed globally by Mediaid Pharmacy, Sunitix gives patients worldwide access to advanced targeted cancer therapy without the financial burden of brand-name alternatives. For patients and physicians seeking a proven, affordable, and accessible Sunitinib option with worldwide delivery, Sunitix from Mediaid Pharmacy is the trusted choice.
Frequently Asked Questions About Sunitix (Sunitinib)
What is Sunitix (Sunitinib) used for?
Sunitix (Sunitinib) is used to treat adult patients with advanced Renal Cell Carcinoma (kidney cancer), Gastrointestinal Stromal Tumour (GIST) after progression on or intolerance to imatinib, and progressive, well-differentiated Pancreatic Neuroendocrine Tumours. It works by blocking multiple receptor tyrosine kinases that tumours rely on to grow and form new blood vessels.
How should I take Sunitix (Sunitinib)?
For GIST and RCC, Sunitix is taken orally once daily, with or without food, for 4 weeks followed by a 2-week break, repeated in 6-week cycles. Pancreatic neuroendocrine tumours are usually treated with a lower dose taken continuously without a break. Always follow your oncologist’s exact instructions, as the schedule differs by condition.
What strength is Sunitix (Sunitinib) available in?
This Sunitix pack is available in a 50mg capsule, supplied as 1 x 6 capsules. The 50mg strength is the standard dose used for GIST and RCC on the 4-weeks-on, 2-weeks-off schedule.
Is Sunitix the same as Sutent (Sunitinib by Pfizer)?
Yes. Sunitix is the generic equivalent of Sutent. Both contain the same active ingredient, Sunitinib, and work through the same multi-targeted receptor tyrosine kinase inhibition mechanism. Sunitix is manufactured by Beacon Pharmaceuticals Ltd. in Bangladesh and offers the same clinical mechanism as Sutent at a significantly lower cost.
What are the side effects of Sunitix (Sunitinib)?
Common side effects include fatigue, diarrhoea, hand-foot skin reaction, high blood pressure, and taste changes. Serious but less common risks include liver injury, heart dysfunction, serious bleeding, and thyroid or adrenal problems. Always consult your oncologist for a complete assessment of your individual risks and benefits before starting treatment.
Can Sunitix be used with other medications?
Sunitix should not be combined with strong CYP3A4 inhibitors or inducers without a physician-directed dose adjustment. Avoid grapefruit products during treatment, and use caution with medicines that affect the QT interval. Always inform your physician of all medications, supplements, and herbal products you are taking before starting Sunitix.
Is Sunitix (Sunitinib) safe during pregnancy or breastfeeding?
No. Sunitix is not recommended during pregnancy or breastfeeding, as it can cause foetal harm. Women of childbearing potential should use effective contraception during treatment, as advised by their physician. Please consult your physician before starting treatment if you are pregnant, planning to become pregnant, or breastfeeding.
Can I order Sunitix (Sunitinib) online with worldwide shipping?
Yes. Mediaid Pharmacy supplies Sunitix (Sunitinib) 50mg globally with worldwide shipping. Contact us via WhatsApp, phone, or WeChat at +8801773428128 or email us at info@mediaidpharmacy.com to enquire about pricing, availability, and delivery to your country.
Order Sunitix (Sunitinib) 50mg with Worldwide Shipping
Phone / WhatsApp / WeChat: +8801773428128 | Email: info@mediaidpharmacy.com
