Lenvaxen 4 MG And 10 MG (Lenvatinib)

Product Name : Lenvaxen
Generic Name : Lenvatinib
Formulation : Capsule
Available Pack Size : 30’s
Available Strengths : 4 mg and 10 mg
Registrations : Export Only

Product Information

Lenvaxen (Lenvatinib) 4mg and 10mg is an oral multi-targeted receptor tyrosine kinase inhibitor used to treat radioactive iodine-refractory Differentiated Thyroid Cancer (DTC), unresectable Hepatocellular Carcinoma (HCC), advanced Renal Cell Carcinoma (RCC), and advanced Endometrial Carcinoma. It works by inhibiting VEGFR1-3, FGFR1-4, PDGFR-alpha, RET, and KIT, blocking the angiogenic and growth signalling pathways that solid tumours depend on to grow new blood vessels and spread. Manufactured by Everest Pharmaceuticals Ltd., Bangladesh and globally supplied by Mediaid Pharmacy with worldwide shipping.

Basic Product Information of Lenvaxen (Lenvatinib) 4mg and 10mg

Brand Name Lenvaxen (Lenvatinib)
Generic Name Lenvatinib (as Lenvatinib Mesylate) INN
Drug Class Multi-Targeted Receptor Tyrosine Kinase Inhibitor
Available Strengths 4mg and 10mg
Formulation Capsule
Pack Size 30 Capsules per Pack (Each Strength)
Primary Indication Differentiated Thyroid Cancer, Hepatocellular Carcinoma, Renal Cell Carcinoma and Endometrial Carcinoma
Regulatory Approvals USFDA Approved (DTC, HCC, RCC, Endometrial Carcinoma). EMA Approved.
Originator Brand Lenvima by Eisai / Merck
Manufacturer Everest Pharmaceuticals Ltd., Dhaka, Bangladesh
Global Supplier Mediaid Pharmacy, Worldwide Shipping Available
Registration Status Export Only – Manufactured for International Markets
Storage Conditions Store below 30 degrees Celsius. Keep in a dry place away from light and moisture. Keep out of the reach of children.

How Lenvaxen (Lenvatinib) Works

Lenvaxen contains Lenvatinib, an oral multi-targeted receptor tyrosine kinase inhibitor with potent antiangiogenic properties. Lenvatinib inhibits the kinase activity of VEGFR-1, -2, and -3, FGFR-1, -2, -3, and -4, PDGFR-alpha, KIT (CD117), and RET, receptors involved in tumour angiogenesis (the formation of new blood vessels that feed a tumour), tumour growth, and cancer progression.

By blocking VEGF- and FGF-driven angiogenesis alongside KIT-dependent signalling and RET-fusion or RET-mutant driven tumour growth, Lenvaxen cuts off the blood supply tumours depend on while directly inhibiting proliferation of malignant cells. This broad, multi-pathway mechanism has shown activity across several difficult-to-treat solid tumour types, including thyroid, liver, kidney, and endometrial cancers.

Lenvaxen is taken as a once-daily oral capsule, used as monotherapy in thyroid and liver cancer, and in combination with other agents such as everolimus or pembrolizumab in kidney and endometrial cancer, depending on the specific indication and treatment line.

Indications for Lenvaxen (Lenvatinib)

Lenvaxen (Lenvatinib) is indicated for the following conditions:

Differentiated Thyroid Cancer (DTC)

For adult patients with locally recurrent or metastatic, progressive, radioactive iodine-refractory differentiated thyroid cancer, as monotherapy.

Hepatocellular Carcinoma (HCC)

For the first-line treatment of adult patients with unresectable hepatocellular carcinoma, as monotherapy.

Renal Cell Carcinoma (RCC)

In combination with everolimus, for adult patients with advanced RCC following one prior anti-angiogenic therapy; or in combination with pembrolizumab, as first-line treatment for advanced RCC.

Endometrial Carcinoma

In combination with pembrolizumab, for adult patients with advanced endometrial carcinoma that is not MSI-H or dMMR, with disease progression following prior systemic therapy who are not candidates for curative surgery or radiation.

Benefits of Lenvaxen (Lenvatinib) 4mg and 10mg

Broad Multi-Cancer Coverage

Approved across thyroid, liver, kidney, and endometrial cancer, Lenvaxen supports patients across four distinct and difficult-to-treat cancer types.

Proven First-Line HCC Option

Lenvatinib demonstrated noninferiority to sorafenib for overall survival in unresectable hepatocellular carcinoma, establishing it as a standard first-line monotherapy option.

Combination-Ready

Lenvaxen is designed to be used both as monotherapy and in combination with everolimus or pembrolizumab, giving oncologists flexibility across treatment lines and cancer types.

Affordable Alternative to Lenvima

Lenvaxen contains the same active ingredient as Lenvima by Eisai and Merck, at a significantly lower cost, making long-term targeted therapy more financially accessible.

Flexible Capsule Strengths

The 4mg and 10mg capsules can be combined to reach any of the several body-weight and indication-specific starting doses used across Lenvaxen’s approved indications.

cGMP Certified Manufacturing

Produced by Everest Pharmaceuticals Ltd. under cGMP-compliant manufacturing standards, helping ensure consistent quality, purity, and potency in every batch of Lenvaxen capsules.

How to Take Lenvaxen (Lenvatinib)

Route: Oral, taken by mouth, at approximately the same time each day. Capsules should be swallowed whole.

Standard dose for DTC: 24mg once daily (two 10mg capsules and one 4mg capsule), continued until disease progression or unacceptable toxicity.

Standard dose for HCC: 12mg once daily (three 4mg capsules) for patients weighing 60kg or more, or 8mg once daily (two 4mg capsules) for patients weighing under 60kg, as monotherapy.

Standard dose for RCC: 18mg once daily (one 10mg capsule and two 4mg capsules) in combination with everolimus 5mg once daily, following one prior anti-angiogenic therapy; or 20mg once daily (two 10mg capsules) in combination with pembrolizumab as first-line treatment.

Standard dose for endometrial carcinoma: 20mg once daily (two 10mg capsules) in combination with pembrolizumab.

With food: Can be taken with or without food.

Missed dose: If a dose is missed and cannot be taken within 12 hours, skip the missed dose and take the next dose at the usual time.

Renal or hepatic impairment: Severe renal or hepatic impairment requires a reduced starting dose, individualised by indication (for example, 14mg once daily for DTC, or 10mg once daily for RCC or endometrial carcinoma). No adjustment is generally required for mild to moderate impairment.

Paediatric use: The safety and efficacy of Lenvaxen in children and adolescents have not been established. No data are currently available.

Prescription Medication. Lenvaxen carries important risks of hypertension (which may be severe), cardiac dysfunction, arterial thromboembolic events, hepatotoxicity, renal impairment or failure, gastrointestinal perforation and fistula formation, and QT interval prolongation. Treatment should only be initiated and monitored by an oncologist experienced in managing these risks, with baseline blood pressure, cardiac, liver, and thyroid assessment before starting. Always follow your prescribing physician’s instructions.

Monitoring and Dosage Adjustments

Regular monitoring is essential throughout Lenvaxen treatment. Your oncologist will monitor blood pressure, checked weekly during the first two months and periodically thereafter, liver function tests, renal function and urine protein, thyroid-stimulating hormone (TSH) levels, and cardiac function in patients with cardiac risk factors. Monitoring also includes serum calcium and periodic ECG where indicated. Report any severe headache, chest pain, breathlessness, severe abdominal pain, unusual bleeding, swelling, or signs of infection to your doctor immediately.

Drug Interactions and Important Information

Use with caution alongside other medicines known to prolong the QTc interval, and inform your physician of any history of hypertension, cardiac disease, or thyroid disorders before starting treatment. When Lenvaxen is used in combination with everolimus or pembrolizumab, refer also to the prescribing information for those medicines, as combination regimens carry their own additional monitoring requirements.

Surgery or invasive procedures should be planned around Lenvaxen treatment, as it may impair wound healing; treatment is typically interrupted before elective surgery. Women of childbearing potential should use effective contraception during treatment and for at least 30 days after the final dose. Always inform your physician of all medications, supplements, and herbal products you are currently taking before starting Lenvaxen.

Side Effects and Precautions

Common Side Effects

Hypertension

Fatigue and asthenia

Diarrhoea and decreased appetite

Nausea and vomiting

Weight loss

Hypothyroidism (elevated TSH)

Palmar-plantar erythrodysesthesia (hand-foot syndrome)

Proteinuria and stomatitis

Serious Warnings and Precautions

Cardiac dysfunction and arterial thromboembolic events, including heart attack and stroke.

Hepatotoxicity, including rare liver failure.

Renal impairment or failure.

Gastrointestinal perforation and fistula formation.

QT interval prolongation and reversible posterior leukoencephalopathy syndrome (RPLS), both rare.

Haemorrhagic events and impaired wound healing.

Embryo-foetal toxicity. Not recommended during pregnancy or breastfeeding.

Who Should Use Lenvaxen (Lenvatinib)?

Lenvaxen is suitable for adult patients diagnosed with radioactive iodine-refractory, locally recurrent or metastatic differentiated thyroid cancer, unresectable hepatocellular carcinoma requiring first-line therapy, advanced renal cell carcinoma requiring combination therapy, or advanced endometrial carcinoma that has progressed on prior systemic therapy. It is prescribed by medical oncologists experienced in managing multikinase inhibitor therapy and its associated cardiovascular, renal, and hepatic risks. A thorough medical assessment including blood pressure, cardiac evaluation, liver and thyroid function, and urine protein is required before initiating treatment.

Manufacturer: Everest Pharmaceuticals Ltd.

Everest Pharmaceuticals Ltd. is a vertically integrated pharmaceutical company based in Dhaka, Bangladesh, focused on complex, technology-driven specialty medicines across oncology, nephrology, and virology. Operating under Bangladesh’s TRIPS/Doha Declaration exemption for least-developed countries, Everest manufactures advanced generics such as Lenvaxen under cGMP-compliant standards, with the stated mission of making high-cost, life-saving medicines accessible and affordable to patients around the world. Lenvaxen is one of Everest’s specialty oncology products, offering a bioequivalent alternative to Lenvima by Eisai and Merck at a fraction of the cost.

Global Supplier: Mediaid Pharmacy with Worldwide Shipping

Mediaid Pharmacy is a trusted global supplier of specialty and oncology medications. We ensure Lenvaxen (Lenvatinib) is accessible to patients and healthcare providers worldwide through reliable worldwide shipping. Whether you are located in South Asia, the Middle East, Africa, Europe, or beyond, Mediaid Pharmacy provides fast and reliable delivery with full order support. Contact us directly via WhatsApp, phone, or WeChat for pricing, availability, and delivery enquiries.

Why Choose Lenvaxen (Lenvatinib) from Mediaid Pharmacy?

Lenvaxen represents a well-established, versatile option across four distinct cancer types. As the generic equivalent of Lenvima by Eisai and Merck, it delivers the same active ingredient, Lenvatinib, with the same proven multi-target receptor tyrosine kinase inhibition mechanism at a dramatically more affordable price. Manufactured by Everest Pharmaceuticals Ltd. under cGMP-compliant standards and distributed globally by Mediaid Pharmacy, Lenvaxen gives patients worldwide access to advanced targeted cancer therapy without the financial burden of brand-name alternatives. For patients and physicians seeking a proven, affordable, and accessible Lenvatinib option with worldwide delivery, Lenvaxen from Mediaid Pharmacy is the trusted choice.

Frequently Asked Questions About Lenvaxen (Lenvatinib)

What is Lenvaxen (Lenvatinib) used for?

Lenvaxen (Lenvatinib) is used to treat adult patients with radioactive iodine-refractory differentiated thyroid cancer, unresectable hepatocellular carcinoma, advanced renal cell carcinoma (in combination with everolimus or pembrolizumab), and advanced endometrial carcinoma (in combination with pembrolizumab). It works by blocking multiple receptor tyrosine kinases that tumours rely on to grow and form new blood vessels.

How should I take Lenvaxen (Lenvatinib)?

Lenvaxen is taken orally, once daily, with or without food. The dose depends on the condition being treated: 24mg for thyroid cancer, 12mg or 8mg (by body weight) for liver cancer, 18mg or 20mg for kidney cancer depending on the combination used, and 20mg for endometrial cancer. Always follow your oncologist’s exact instructions, as dosing is highly individualised.

What strengths is Lenvaxen (Lenvatinib) available in?

Lenvaxen is available in 4mg and 10mg capsules, each supplied in a pack of 30 capsules. These two strengths can be combined to reach any of the various starting doses used across Lenvaxen’s different approved indications.

Is Lenvaxen the same as Lenvima (Lenvatinib by Eisai/Merck)?

Yes. Lenvaxen is the generic equivalent of Lenvima. Both contain the same active ingredient, Lenvatinib, and work through the same multi-targeted receptor tyrosine kinase inhibition mechanism. Lenvaxen is manufactured by Everest Pharmaceuticals Ltd. in Bangladesh and offers the same clinical mechanism as Lenvima at a significantly lower cost.

What are the side effects of Lenvaxen (Lenvatinib)?

Common side effects include high blood pressure, fatigue, diarrhoea, decreased appetite, and hand-foot skin reaction. Serious but less common risks include heart problems, liver injury, kidney impairment, gastrointestinal perforation, and abnormal heart rhythm. Always consult your oncologist for a complete assessment of your individual risks and benefits before starting treatment.

Can Lenvaxen be used with other medications?

Depending on the cancer type, Lenvaxen may be prescribed in combination with everolimus or pembrolizumab as part of an approved treatment regimen. Use caution with other medicines that affect the QT interval or blood pressure, and treatment is usually paused before planned surgery. Always inform your physician of all medications, supplements, and herbal products you are taking before starting Lenvaxen.

Is Lenvaxen (Lenvatinib) safe during pregnancy or breastfeeding?

No. Lenvaxen is not recommended during pregnancy or breastfeeding, as it can cause foetal harm. Women of childbearing potential should use effective contraception during treatment and for at least 30 days after the final dose. Please consult your physician before starting treatment if you are pregnant, planning to become pregnant, or breastfeeding.

Can I order Lenvaxen (Lenvatinib) online with worldwide shipping?

Yes. Mediaid Pharmacy supplies Lenvaxen (Lenvatinib) 4mg and 10mg globally with worldwide shipping. Contact us via WhatsApp, phone, or WeChat at +8801773428128 or email us at info@mediaidpharmacy.com to enquire about pricing, availability, and delivery to your country.

Order Lenvaxen (Lenvatinib) 4mg and 10mg with Worldwide Shipping

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