Velpanex 400 MG And 100 MG (Sofosbuvir)
Product Name : Velpanex
Generic Name : Sofosbuvir
Formulation : Tablet
Available Pack Size : 28’s
Available Strengths : 400 mg and 100 mg
Registrations : Export Only
Product Information
Velpanex (Sofosbuvir 400mg / Velpatasvir 100mg) is a fixed-dose, pangenotypic combination of two direct-acting antivirals used to treat chronic Hepatitis C Virus (HCV) infection across genotypes 1 through 6. It works by combining an NS5B polymerase inhibitor (Sofosbuvir) with an NS5A inhibitor (Velpatasvir), blocking two essential proteins the virus needs to replicate, in a single once-daily tablet. Manufactured by Everest Pharmaceuticals Ltd., Bangladesh and globally supplied by Mediaid Pharmacy with worldwide shipping.
Basic Product Information of Velpanex (Sofosbuvir/Velpatasvir)
| Brand Name | Velpanex (Sofosbuvir/Velpatasvir) |
| Generic Name | Sofosbuvir 400mg / Velpatasvir 100mg (Fixed-Dose Combination, per tablet) |
| Drug Class | HCV NS5B Polymerase Inhibitor + HCV NS5A Inhibitor (Direct-Acting Antiviral Combination) |
| Strength per Tablet | Sofosbuvir 400mg and Velpatasvir 100mg (fixed-dose combination in a single tablet) |
| Formulation | Film-Coated Tablet |
| Pack Size | 28 Tablets per Pack |
| Primary Indication | Chronic Hepatitis C Virus (HCV) Infection, Genotypes 1 to 6 |
| Regulatory Approvals | USFDA Approved (Pangenotypic HCV, Ages 3 and Above). EMA Approved. Carries an FDA Boxed Warning for HBV reactivation risk. |
| Originator Brand | Epclusa by Gilead Sciences |
| Manufacturer | Everest Pharmaceuticals Ltd., Dhaka, Bangladesh |
| Global Supplier | Mediaid Pharmacy, Worldwide Shipping Available |
| Registration Status | Export Only – Manufactured for International Markets |
| Storage Conditions | Store below 30 degrees Celsius. Keep in a dry place away from light and moisture. Keep out of the reach of children. |
How Velpanex (Sofosbuvir/Velpatasvir) Works
Each Velpanex tablet combines two direct-acting antivirals that block different, essential steps of the Hepatitis C virus (HCV) life cycle. Sofosbuvir is an inhibitor of the HCV NS5B RNA-dependent RNA polymerase, the enzyme the virus uses to copy its genetic material. Velpatasvir is an inhibitor of NS5A, a protein essential for HCV RNA replication and the assembly of new virus particles.
By blocking viral replication at two separate points simultaneously, Velpanex achieves high cure rates across all six major HCV genotypes, making it a pangenotypic treatment option. In large clinical trials, this combination achieved sustained virologic response rates (a functional cure) of 95 to 99% in patients without decompensated cirrhosis, and high response rates even in patients with more advanced liver disease when combined with ribavirin.
Velpanex is taken as a single tablet, once daily, with or without food, and was the first fixed-dose combination approved for the treatment of all major HCV genotypes without the need for prior genotype testing in many treatment scenarios.
Indications for Velpanex (Sofosbuvir/Velpatasvir)
Velpanex (Sofosbuvir/Velpatasvir) is indicated for the following conditions:
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Chronic HCV Without Cirrhosis or With Compensated Cirrhosis For adult and paediatric patients aged 3 years and older with chronic HCV genotype 1, 2, 3, 4, 5, or 6 infection who have no cirrhosis or have compensated cirrhosis. |
Decompensated Cirrhosis, With Ribavirin For adult and paediatric patients with chronic HCV and decompensated (advanced) cirrhosis, used in combination with ribavirin. |
Benefits of Velpanex (Sofosbuvir/Velpatasvir)
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Single-Tablet, Once-Daily Dosing Velpanex is taken as just one tablet, once daily, one of the simplest regimens available for chronic HCV, without the need to take multiple tablets together. |
Pangenotypic Coverage Velpanex is effective across all six major HCV genotypes, simplifying treatment selection in many clinical scenarios. |
Very High Cure Rates Clinical trials of Sofosbuvir/Velpatasvir demonstrated sustained virologic response rates of 95 to 99% in patients without decompensated cirrhosis. |
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Affordable Alternative to Epclusa Velpanex contains the same active ingredients as Epclusa by Gilead Sciences, at a significantly lower cost, making curative HCV therapy more financially accessible worldwide. |
Suitable for Advanced Liver Disease When combined with ribavirin, Velpanex is also an option for patients with decompensated cirrhosis, a population that some other regimens cannot treat. |
cGMP Certified Manufacturing Produced by Everest Pharmaceuticals Ltd. under cGMP-compliant manufacturing standards, helping ensure consistent quality, purity, and potency in every batch of Velpanex tablets. |
How to Take Velpanex (Sofosbuvir/Velpatasvir)
Route: Oral, with or without food. The tablet should be swallowed whole.
Standard dose: One tablet (Sofosbuvir 400mg / Velpatasvir 100mg) taken orally, once daily.
Treatment duration: Typically 12 weeks for patients without cirrhosis or with compensated cirrhosis. Patients with decompensated cirrhosis take Velpanex in combination with ribavirin, also generally for 12 weeks, as directed by the prescribing physician.
Missed dose: If a dose is missed and remembered within 18 hours of the usual time, take it as soon as possible; if more than 18 hours have passed, skip the missed dose and resume the normal schedule the next day.
Hepatic impairment: No dose adjustment is required for mild, moderate, or severe hepatic impairment, including decompensated cirrhosis (used with ribavirin in this population).
Renal impairment: No dose adjustment is required based on renal function, including patients with severe renal impairment or on dialysis.
Acid-reducing agents: Antacids, H2-receptor antagonists, and proton pump inhibitors can reduce Velpatasvir absorption; separate dosing as directed by the prescribing physician, or avoid where possible.
Paediatric use: Approved for paediatric patients 3 years of age and older; weight-based dosing and formulation guidance for younger patients should be directed by a specialist.
Monitoring and Dosage Adjustments
Before starting Velpanex, all patients must be tested for current or prior Hepatitis B virus infection. Your physician will also assess baseline liver function, particularly in patients with decompensated cirrhosis. When Velpanex is used with amiodarone, or in any patient with cardiac risk factors, close cardiac monitoring is required due to the risk of serious slow heart rate (bradycardia). During treatment, monitoring may include periodic liver function tests and, in patients also taking ribavirin, monitoring in line with ribavirin’s own prescribing information. Report any yellowing of the skin or eyes, dizziness, fainting, extreme fatigue, or a very slow or irregular heartbeat to your doctor immediately.
Drug Interactions and Important Information
Velpanex should not be used with amiodarone, unless no alternative treatment is available, due to a risk of serious symptomatic bradycardia, which has led to fatal cases and the need for a pacemaker when similar sofosbuvir-containing regimens were combined with amiodarone, particularly alongside beta-blockers or in patients with underlying heart conditions.
Avoid concomitant use of Velpanex with P-glycoprotein inducers and moderate to strong inducers of CYP2B6, CYP2C8, or CYP3A4, such as rifampin, St. John’s Wort, and carbamazepine, as these can significantly decrease Sofosbuvir and/or Velpatasvir plasma concentrations and reduce effectiveness. Acid-reducing medications should be separated from Velpanex dosing as directed. Always inform your physician of all medications, supplements, and herbal products you are currently taking before starting Velpanex.
Side Effects and Precautions
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Common Side Effects Headache Fatigue Nausea Diarrhoea Difficulty sleeping |
Serious Warnings and Precautions Hepatitis B virus reactivation in HCV/HBV coinfected patients, potentially fatal. Requires baseline HBV testing. Serious symptomatic bradycardia when combined with amiodarone, in rare cases fatal. Reduced therapeutic effect if combined with certain enzyme-inducing medications. |
Who Should Use Velpanex (Sofosbuvir/Velpatasvir)?
Velpanex is suitable for adult and paediatric patients aged 3 years and older with chronic Hepatitis C virus infection across genotypes 1 through 6, including patients without cirrhosis, with compensated cirrhosis, or with decompensated cirrhosis (in combination with ribavirin). It is prescribed by hepatologists, gastroenterologists, and infectious disease specialists experienced in managing chronic HCV. A thorough medical assessment including HBV testing, baseline liver function, and a review of concomitant medications (particularly amiodarone) is required before initiating treatment.
Manufacturer: Everest Pharmaceuticals Ltd.
Everest Pharmaceuticals Ltd. is a vertically integrated pharmaceutical company based in Dhaka, Bangladesh, focused on complex, technology-driven specialty medicines across oncology, nephrology, and virology. Operating under Bangladesh’s TRIPS/Doha Declaration exemption for least-developed countries, Everest manufactures advanced generics such as Velpanex under cGMP-compliant standards, with the stated mission of making high-cost, life-saving medicines accessible and affordable to patients around the world. Velpanex is one of Everest’s specialty virology products, offering a bioequivalent alternative to Epclusa by Gilead Sciences at a fraction of the cost.
Global Supplier: Mediaid Pharmacy with Worldwide Shipping
Mediaid Pharmacy is a trusted global supplier of specialty medications. We ensure Velpanex (Sofosbuvir/Velpatasvir) is accessible to patients and healthcare providers worldwide through reliable worldwide shipping. Whether you are located in South Asia, the Middle East, Africa, Europe, or beyond, Mediaid Pharmacy provides fast and reliable delivery with full order support. Contact us directly via WhatsApp, phone, or WeChat for pricing, availability, and delivery enquiries.
Why Choose Velpanex (Sofosbuvir/Velpatasvir) from Mediaid Pharmacy?
Velpanex represents one of the simplest and most effective options in modern Hepatitis C treatment. As the generic equivalent of Epclusa by Gilead Sciences, it delivers the same active ingredients, Sofosbuvir and Velpatasvir, with the same proven pangenotypic mechanism and single-tablet, once-daily regimen at a dramatically more affordable price. Manufactured by Everest Pharmaceuticals Ltd. under cGMP-compliant standards and distributed globally by Mediaid Pharmacy, Velpanex gives patients worldwide access to curative HCV therapy without the financial burden of brand-name alternatives. For patients and physicians seeking a proven, affordable, and accessible Sofosbuvir/Velpatasvir option with worldwide delivery, Velpanex from Mediaid Pharmacy is the trusted choice.
Frequently Asked Questions About Velpanex (Sofosbuvir/Velpatasvir)
What is Velpanex used for?
Velpanex (Sofosbuvir/Velpatasvir) is used to treat chronic Hepatitis C virus infection across genotypes 1 through 6 in patients aged 3 years and older, including those without cirrhosis, with compensated cirrhosis, or with decompensated cirrhosis when combined with ribavirin. It works by blocking two essential steps in the HCV replication process.
How should I take Velpanex?
Velpanex is taken as a single tablet, once daily, with or without food. Treatment typically lasts 12 weeks. It is important to complete the full prescribed course even if you feel well, and not to combine Velpanex with amiodarone unless specifically directed by your physician.
What strength is Velpanex available in?
Each Velpanex tablet is a fixed-dose combination containing 400mg of Sofosbuvir and 100mg of Velpatasvir, supplied in a pack of 28 tablets, enough for a standard 4-week supply at the once-daily dose.
Is Velpanex the same as Epclusa (Sofosbuvir/Velpatasvir by Gilead)?
Yes. Velpanex is the generic equivalent of Epclusa. Both contain the same active ingredients, Sofosbuvir and Velpatasvir, in the identical fixed-dose combination. Velpanex is manufactured by Everest Pharmaceuticals Ltd. in Bangladesh and delivers the same clinical mechanism as Epclusa at a significantly lower cost.
What are the side effects of Velpanex?
Common side effects include headache, fatigue, nausea, and diarrhoea. The most important risks are Hepatitis B virus reactivation in patients also infected with HBV, and serious slow heart rate if combined with amiodarone. Always consult your physician for a complete assessment of your individual risks and benefits before starting treatment.
Can Velpanex be used with other medications?
Velpanex should not be combined with amiodarone unless no other option is available, due to a risk of serious slow heart rate. Avoid strong enzyme-inducing medications such as rifampin, St. John’s Wort, and carbamazepine, as these reduce effectiveness. Acid-reducing medications should be separated from Velpanex dosing. Always inform your physician of all medications, supplements, and herbal products you are taking before starting Velpanex.
Is Velpanex safe during pregnancy or breastfeeding?
Please consult your physician before starting treatment if you are pregnant, planning to become pregnant, or breastfeeding, especially if ribavirin is also being considered, as ribavirin carries its own significant pregnancy-related restrictions.
Can I order Velpanex online with worldwide shipping?
Yes. Mediaid Pharmacy supplies Velpanex (Sofosbuvir/Velpatasvir) globally with worldwide shipping. Contact us via WhatsApp, phone, or WeChat at +8801773428128 or email us at info@mediaidpharmacy.com to enquire about pricing, availability, and delivery to your country.
Order Velpanex (Sofosbuvir 400mg / Velpatasvir 100mg) with Worldwide Shipping
Phone / WhatsApp / WeChat: +8801773428128 | Email: info@mediaidpharmacy.com
