Product Information
Lenvaxen (Lenvatinib) 10mg is a multi-receptor tyrosine kinase inhibitor used to treat Differentiated Thyroid Cancer (DTC), unresectable Hepatocellular Carcinoma (HCC), advanced Renal Cell Carcinoma (RCC) in combination with everolimus or pembrolizumab, and advanced Endometrial Carcinoma in combination with pembrolizumab. It works by inhibiting VEGFR-1, -2, and -3, FGFR-1 through -4, PDGFR-alpha, RET, and KIT, blocking both tumour angiogenesis and several additional signalling pathways implicated in tumour growth and progression. Manufactured by Everest Pharmaceuticals Ltd., Bangladesh and globally supplied by Mediaid Pharmacy with worldwide shipping.
Basic Product Information of Lenvaxen (Lenvatinib) 10mg
| Brand Name | Lenvaxen (Lenvatinib) |
| Generic Name | Lenvatinib (as Lenvatinib Mesylate) INN |
| Drug Class | Multi-Receptor Tyrosine Kinase Inhibitor (VEGFR/FGFR/PDGFR/RET/KIT Inhibitor) |
| Available Strength | 10mg |
| Formulation | Capsule |
| Pack Size | 30 Capsules per Pack |
| Primary Indication | Differentiated Thyroid Cancer, Hepatocellular Carcinoma, Renal Cell Carcinoma and Endometrial Carcinoma |
| Regulatory Approvals | USFDA Approved (DTC, HCC, RCC Combinations, Endometrial Combination). EMA Approved. |
| Originator Brand | Lenvima by Eisai / Merck |
| Manufacturer | Everest Pharmaceuticals Ltd., Dhaka, Bangladesh |
| Global Supplier | Mediaid Pharmacy, Worldwide Shipping Available |
| Registration Status | Export Only – Manufactured for International Markets |
| Storage Conditions | Store below 30 degrees Celsius. Keep in a dry place away from light and moisture. Keep out of the reach of children. |
How Lenvaxen (Lenvatinib) Works
Lenvaxen contains Lenvatinib, an oral multi-target kinase inhibitor that blocks a wide range of receptor tyrosine kinases involved in tumour growth, including VEGFR-1, VEGFR-2, and VEGFR-3, FGFR-1 through FGFR-4, PDGFR-alpha, RET, and KIT. By inhibiting VEGFR signalling, Lenvaxen suppresses the angiogenesis tumours depend on to form new blood vessels, while its inhibition of FGFR, PDGFR, RET, and KIT provides additional, complementary anti-tumour activity across several distinct cancer types.
This broad kinase-inhibition profile underlies Lenvaxen’s use both as a standalone treatment (in DTC and HCC) and in combination with immune checkpoint or mTOR-targeted therapies (in RCC and endometrial carcinoma), where the different mechanisms of each agent work together for a stronger overall anti-tumour effect.
Lenvaxen is taken as a once-daily oral capsule, with the exact dose built from a combination of capsule strengths tailored to the specific cancer type and companion therapy being used.
Indications for Lenvaxen (Lenvatinib)
Lenvaxen (Lenvatinib) is indicated for the following conditions:
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Differentiated Thyroid Cancer (DTC) As monotherapy for locally recurrent or metastatic, progressive, radioactive iodine-refractory DTC. |
Hepatocellular Carcinoma (HCC) As first-line monotherapy for unresectable hepatocellular carcinoma. |
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Renal Cell Carcinoma (RCC) In combination with everolimus, following one prior anti-angiogenic therapy; or in combination with pembrolizumab, as first-line treatment for advanced RCC. |
Endometrial Carcinoma In combination with pembrolizumab, for advanced endometrial carcinoma that is not MSI-H or dMMR, in patients who have progressed after prior systemic therapy and are not candidates for curative surgery or radiation. |
Benefits of Lenvaxen (Lenvatinib) 10mg
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Broadest Kinase-Target Coverage Lenvaxen’s activity against VEGFR, FGFR, PDGFR, RET, and KIT gives it one of the broadest target profiles among approved multikinase inhibitors. |
Four Distinct Cancer Indications Approved across thyroid, liver, kidney, and endometrial cancer, Lenvaxen is one of the most versatile targeted therapies in oncology practice. |
Effective in Combination Regimens Paired with pembrolizumab or everolimus, Lenvaxen has demonstrated strong outcomes in RCC and endometrial carcinoma, expanding options for patients with advanced disease. |
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Affordable Alternative to Lenvima Lenvaxen contains the same active ingredient as Lenvima by Eisai/Merck, at a significantly lower cost, making broad multikinase-inhibitor therapy more financially accessible. |
Companion Strength Available Mediaid Pharmacy also stocks Lenvaxen 4mg, allowing physicians to build the exact dose needed for every approved indication. |
cGMP Certified Manufacturing Produced by Everest Pharmaceuticals Ltd. under cGMP-compliant manufacturing standards, helping ensure consistent quality, purity, and potency in every batch of Lenvaxen capsules. |
How to Take Lenvaxen (Lenvatinib)
Route: Oral, with or without food, at approximately the same time each day. Capsules should be swallowed whole.
DTC dose: 24mg once daily (two 10mg capsules plus one 4mg capsule).
HCC dose: Patients weighing 60kg or more: 12mg once daily (using 4mg capsules only). Patients weighing less than 60kg: 8mg once daily (using 4mg capsules only).
RCC dose with everolimus: 18mg once daily (one 10mg capsule plus two 4mg capsules), combined with everolimus 5mg once daily.
RCC dose with pembrolizumab: 20mg once daily (two 10mg capsules), combined with pembrolizumab as directed.
Endometrial carcinoma dose with pembrolizumab: 20mg once daily (two 10mg capsules), combined with pembrolizumab as directed.
Missed dose: If a dose is missed and cannot be taken within 12 hours, skip the missed dose and take the next dose at its normal scheduled time.
Dose modification for toxicity: Dose interruption and/or reduction in defined steps may be required to manage hypertension, proteinuria, or other adverse reactions, as directed by the prescribing oncologist.
Monitoring and Dosage Adjustments
Regular monitoring is essential throughout Lenvaxen treatment. Your oncologist will monitor blood pressure closely, particularly during the first cycle, along with cardiac function, liver function tests, renal function, and urine protein. Monitoring also includes periodic thyroid function, serum calcium, and, where indicated, ECG monitoring for QT prolongation. Report any severe headache, chest pain, unusual bleeding, severe abdominal pain, decreased urination, muscle cramps, vision changes, confusion, or seizures to your doctor immediately.
Drug Interactions and Important Information
Use with caution alongside other medicines known to prolong the QTc interval, and inform your physician of any medications that affect blood pressure or clotting risk. When Lenvaxen is used with everolimus or pembrolizumab, refer also to the prescribing information for those agents, as they carry their own distinct warnings and monitoring requirements.
Lenvaxen can cause foetal harm and is not recommended during pregnancy or breastfeeding. Women of childbearing potential should use effective contraception during treatment and for at least 30 days after the final dose; men should use effective contraception during treatment and for at least 30 days after the final dose. Always inform your physician of all medications, supplements, and herbal products you are currently taking before starting Lenvaxen.
Side Effects and Precautions
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Common Side Effects Hypertension Fatigue and decreased appetite Diarrhoea and nausea Weight loss and stomatitis Hand-foot skin reaction Proteinuria and dysphonia (voice changes) |
Serious Warnings and Precautions Cardiac dysfunction and arterial thromboembolic events. Hepatotoxicity and renal impairment or failure. Gastrointestinal perforation and fistula formation. QT prolongation, hypocalcaemia, and RPLS (rare). Embryo-foetal toxicity. Not recommended during pregnancy or breastfeeding. |
Who Should Use Lenvaxen (Lenvatinib)?
Lenvaxen is suitable for adult patients with radioactive iodine-refractory differentiated thyroid cancer, unresectable hepatocellular carcinoma, advanced renal cell carcinoma (in combination with everolimus or pembrolizumab), or advanced endometrial carcinoma (in combination with pembrolizumab). It is prescribed by medical oncologists experienced in managing multikinase inhibitor therapy and its associated cardiovascular, hepatic, and renal risks. A thorough medical assessment including blood pressure, cardiac evaluation, liver and renal function, and thyroid function is required before initiating treatment.
Manufacturer: Everest Pharmaceuticals Ltd.
Everest Pharmaceuticals Ltd. is a vertically integrated pharmaceutical company based in Dhaka, Bangladesh, focused on complex, technology-driven specialty medicines across oncology, nephrology, and virology. Operating under Bangladesh’s TRIPS/Doha Declaration exemption for least-developed countries, Everest manufactures advanced generics such as Lenvaxen under cGMP-compliant standards, with the stated mission of making high-cost, life-saving medicines accessible and affordable to patients around the world. Lenvaxen is one of Everest’s specialty oncology products, offering a bioequivalent alternative to Lenvima by Eisai/Merck at a fraction of the cost.
Global Supplier: Mediaid Pharmacy with Worldwide Shipping
Mediaid Pharmacy is a trusted global supplier of specialty and oncology medications. We ensure Lenvaxen (Lenvatinib) is accessible to patients and healthcare providers worldwide through reliable worldwide shipping. Whether you are located in South Asia, the Middle East, Africa, Europe, or beyond, Mediaid Pharmacy provides fast and reliable delivery with full order support. Contact us directly via WhatsApp, phone, or WeChat for pricing, availability, and delivery enquiries.
Why Choose Lenvaxen (Lenvatinib) from Mediaid Pharmacy?
Lenvaxen represents one of the most versatile multikinase inhibitors in modern oncology, spanning thyroid, liver, kidney, and endometrial cancer. As the generic equivalent of Lenvima by Eisai/Merck, it delivers the same active ingredient, Lenvatinib, with the same proven multi-target inhibition mechanism at a dramatically more affordable price. Manufactured by Everest Pharmaceuticals Ltd. under cGMP-compliant standards and distributed globally by Mediaid Pharmacy, Lenvaxen gives patients worldwide access to advanced targeted cancer therapy without the financial burden of brand-name alternatives. For patients and physicians seeking a proven, affordable, and accessible Lenvatinib option with worldwide delivery, Lenvaxen from Mediaid Pharmacy is the trusted choice.
Frequently Asked Questions About Lenvaxen (Lenvatinib)
What is Lenvaxen (Lenvatinib) used for?
Lenvaxen (Lenvatinib) is used to treat radioactive iodine-refractory differentiated thyroid cancer, unresectable hepatocellular carcinoma, advanced renal cell carcinoma (with everolimus or pembrolizumab), and advanced endometrial carcinoma (with pembrolizumab). It works by blocking multiple signalling pathways tumours rely on to grow and form new blood vessels.
How should I take Lenvaxen (Lenvatinib)?
Lenvaxen is taken orally, once daily, with or without food. The exact dose depends on your specific cancer type and any companion medication: 24mg for DTC, 8-12mg for HCC (weight-based), 18mg for RCC with everolimus, or 20mg for RCC or endometrial carcinoma with pembrolizumab. This 10mg strength alone cleanly covers the 20mg pembrolizumab-combination doses; other regimens need the companion 4mg strength. Always follow your oncologist’s exact instructions.
What strength is this Lenvaxen product available in?
This Lenvaxen pack is a 10mg capsule, supplied in a pack of 30 capsules. A companion 4mg strength is also available and is needed to build several of the approved dosing regimens.
Is Lenvaxen the same as Lenvima (Lenvatinib by Eisai/Merck)?
Yes. Lenvaxen is the generic equivalent of Lenvima. Both contain the same active ingredient, Lenvatinib, and work through the same multi-target kinase inhibition mechanism. Lenvaxen is manufactured by Everest Pharmaceuticals Ltd. in Bangladesh and offers the same clinical mechanism as Lenvima at a significantly lower cost.
What are the side effects of Lenvaxen (Lenvatinib)?
Common side effects include high blood pressure, fatigue, decreased appetite, diarrhoea, and hand-foot skin reaction. Serious but less common risks include heart problems, liver injury, kidney impairment, and gastrointestinal perforation. Always consult your oncologist for a complete assessment of your individual risks and benefits before starting treatment.
Can Lenvaxen be used with other medications?
Use caution combining Lenvaxen with other medicines that affect the QT interval, blood pressure, or clotting risk. When used with everolimus or pembrolizumab, both agents carry their own separate warnings and monitoring needs. Always inform your physician of all medications, supplements, and herbal products you are taking before starting Lenvaxen.
Is Lenvaxen (Lenvatinib) safe during pregnancy or breastfeeding?
No. Lenvaxen is not recommended during pregnancy or breastfeeding, as it can cause foetal harm. Effective contraception should be used during treatment and for at least 30 days after the final dose, by both female patients and male patients. Please consult your physician before starting treatment if you are pregnant, planning to become pregnant, or breastfeeding.
Can I order Lenvaxen (Lenvatinib) online with worldwide shipping?
Yes. Mediaid Pharmacy supplies Lenvaxen (Lenvatinib) 10mg globally with worldwide shipping. Contact us via WhatsApp, phone, or WeChat at +8801773428128 or email us at info@mediaidpharmacy.com to enquire about pricing, availability, and delivery to your country.
Order Lenvaxen (Lenvatinib) 10mg with Worldwide Shipping
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