Nexataf 25 MG (Tenofovir)
Product Name : Nexataf
Generic Name : Tenofovir
Formulation : Tablet
Available Pack Size : 30’s
Available Strengths : 25 mg
Registrations : Export Only
Product Information
Nexataf (Tenofovir Alafenamide) 25mg is an oral nucleotide reverse transcriptase inhibitor used for the treatment of chronic Hepatitis B Virus (HBV) infection in adults with compensated liver disease. It works as a prodrug that is converted inside liver cells to tenofovir and then to its active metabolite, which inhibits HBV reverse transcriptase and terminates viral DNA chain formation, suppressing HBV replication. Compared to older tenofovir formulations, Nexataf delivers the active drug more efficiently to liver cells at a much lower dose, resulting in less circulating tenofovir and improved kidney and bone safety parameters. Manufactured by Everest Pharmaceuticals Ltd., Bangladesh and globally supplied by Mediaid Pharmacy with worldwide shipping.
Basic Product Information of Nexataf (Tenofovir Alafenamide) 25mg
| Brand Name | Nexataf (Tenofovir Alafenamide) |
| Generic Name | Tenofovir Alafenamide (as Tenofovir Alafenamide Fumarate) INN, 25mg |
| Drug Class | Nucleotide Reverse Transcriptase Inhibitor (Antiviral) |
| Available Strength | 25mg |
| Formulation | Film-Coated Tablet |
| Pack Size | 30 Tablets per Pack |
| Primary Indication | Chronic Hepatitis B Virus (HBV) Infection with Compensated Liver Disease |
| Regulatory Approvals | USFDA Approved (Ages 6 and Above, Weighing at Least 25kg). EMA Approved. Carries an FDA Boxed Warning for lactic acidosis/hepatomegaly and post-treatment HBV exacerbation. |
| Originator Brand | Vemlidy by Gilead Sciences |
| Manufacturer | Everest Pharmaceuticals Ltd., Dhaka, Bangladesh |
| Global Supplier | Mediaid Pharmacy, Worldwide Shipping Available |
| Registration Status | Export Only – Manufactured for International Markets |
| Storage Conditions | Store below 30 degrees Celsius. Keep in a dry place away from light and moisture. Keep out of the reach of children. |
How Nexataf (Tenofovir Alafenamide) Works
Nexataf contains Tenofovir Alafenamide, a targeted prodrug of tenofovir. After absorption, Tenofovir Alafenamide is converted inside hepatocytes (liver cells) to tenofovir and then to its pharmacologically active metabolite, tenofovir diphosphate. This active form inhibits HBV reverse transcriptase by being incorporated into the growing viral DNA chain, causing DNA chain termination and halting the virus’s ability to replicate.
Because Tenofovir Alafenamide has greater plasma stability and delivers tenofovir to liver cells more efficiently than older tenofovir formulations, it achieves similar antiviral efficacy at less than one-tenth the dose. This results in significantly less tenofovir circulating in the bloodstream, which has been shown to improve kidney and bone laboratory safety parameters compared with higher-dose tenofovir formulations, while maintaining strong, sustained suppression of HBV.
Nexataf is taken as a once-daily oral tablet with food, and is intended for long-term, ongoing suppression of chronic HBV infection rather than a short, fixed-duration course.
Indication for Nexataf (Tenofovir Alafenamide)
Nexataf (Tenofovir Alafenamide) is indicated for the following condition:
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Chronic Hepatitis B Virus (HBV) Infection For the treatment of chronic HBV infection in patients aged 6 years and older, weighing at least 25kg, with compensated liver disease. Patients must be tested for HIV-1 infection before starting Nexataf, as it should not be used alone in patients co-infected with HIV-1 due to the risk of HIV drug resistance developing. |
Benefits of Nexataf (Tenofovir Alafenamide) 25mg
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Low-Dose, Targeted Delivery Nexataf achieves antiviral efficacy comparable to older, higher-dose tenofovir formulations, at less than one-tenth of the dose, by delivering active drug more efficiently directly to liver cells. |
Improved Renal and Bone Safety By reducing the amount of tenofovir circulating in the bloodstream, Nexataf has demonstrated improved kidney and bone laboratory safety parameters compared with older tenofovir formulations. |
Convenient Once-Daily Dosing Nexataf is taken as a single oral tablet, once daily with food, supporting long-term adherence for a chronic, ongoing condition. |
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Affordable Alternative to Vemlidy Nexataf contains the same active ingredient as Vemlidy by Gilead Sciences, at a significantly lower cost, making long-term chronic HBV suppression more financially accessible. |
Long-Term Efficacy Data Long-term clinical trial follow-up has demonstrated sustained efficacy and safety of Tenofovir Alafenamide for chronic HBV treatment over several years. |
cGMP Certified Manufacturing Produced by Everest Pharmaceuticals Ltd. under cGMP-compliant manufacturing standards, helping ensure consistent quality, purity, and potency in every batch of Nexataf tablets. |
How to Take Nexataf (Tenofovir Alafenamide)
Route: Oral, taken with food. The tablet should be swallowed whole.
Standard dose: One 25mg tablet, taken orally, once daily with food. Treatment is generally continued long-term to maintain suppression of HBV, as directed by the prescribing physician.
Missed dose: If a dose is missed and remembered within 18 hours of the usual time, take it with food as soon as possible; if more than 18 hours have passed, skip the missed dose and resume the normal schedule with the next dose.
Renal impairment: Not recommended in patients with a creatinine clearance below 15 mL/min who are not receiving haemodialysis. In patients on chronic haemodialysis, the dose should be administered after completion of the dialysis session.
Hepatic impairment: No dose adjustment is required for mild hepatic impairment (Child-Pugh Class A). Nexataf is not recommended for patients with decompensated liver disease (Child-Pugh Class B or C).
Paediatric use: Approved for paediatric patients 6 years of age and older weighing at least 25kg, with compensated liver disease, as directed by a specialist.
Monitoring and Dosage Adjustments
Before starting Nexataf, all patients must be tested for HIV-1 infection. Your physician will also assess serum creatinine, phosphorus, estimated creatinine clearance, and urine glucose and protein before starting treatment and periodically throughout. Monitoring during treatment includes periodic liver function tests and HBV viral load to confirm ongoing suppression. If Nexataf is discontinued, close clinical and laboratory monitoring must continue for several months afterwards to detect any severe rebound flare of hepatitis B. Report any unusual muscle pain, weakness, difficulty breathing, abdominal pain, nausea, or yellowing of the skin or eyes to your doctor immediately.
Drug Interactions and Important Information
Coadministration of Nexataf is not recommended with oxcarbazepine, phenobarbital, phenytoin, rifabutin, rifampin, rifapentine, or St. John’s Wort, as these are expected to decrease Tenofovir Alafenamide concentrations and reduce its therapeutic effect. Nexataf is a substrate of P-glycoprotein (P-gp) and BCRP, so drugs that strongly affect these transporters may change Nexataf absorption; consult full prescribing information for a complete list of potentially significant interactions.
Nexataf should not be used alone in patients with HIV-1 co-infection, as HIV-1 resistance may develop; a complete antiretroviral regimen should be used in these patients. Always inform your physician of all medications, supplements, and herbal products you are currently taking before starting Nexataf.
Side Effects and Precautions
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Common Side Effects Headache Abdominal pain Fatigue Cough Nausea |
Serious Warnings and Precautions Lactic acidosis and severe hepatomegaly with steatosis, which can be fatal. Severe acute exacerbation of hepatitis B after discontinuation. Requires close post-treatment monitoring. Risk of HIV-1 resistance if used alone in undiagnosed or untreated HIV-1 co-infection. HIV testing required before starting. |
Who Should Use Nexataf (Tenofovir Alafenamide)?
Nexataf is suitable for patients aged 6 years and older, weighing at least 25kg, with chronic Hepatitis B virus infection and compensated liver disease. It is prescribed by hepatologists, gastroenterologists, and infectious disease specialists experienced in managing chronic HBV. A thorough medical assessment including HIV-1 testing, baseline renal function, and liver function is required before initiating treatment, and patients who stop treatment require careful ongoing monitoring.
Manufacturer: Everest Pharmaceuticals Ltd.
Everest Pharmaceuticals Ltd. is a vertically integrated pharmaceutical company based in Dhaka, Bangladesh, focused on complex, technology-driven specialty medicines across oncology, nephrology, and virology. Operating under Bangladesh’s TRIPS/Doha Declaration exemption for least-developed countries, Everest manufactures advanced generics such as Nexataf under cGMP-compliant standards, with the stated mission of making high-cost, life-saving medicines accessible and affordable to patients around the world. Nexataf is one of Everest’s specialty virology products, offering a bioequivalent alternative to Vemlidy by Gilead Sciences at a fraction of the cost.
Global Supplier: Mediaid Pharmacy with Worldwide Shipping
Mediaid Pharmacy is a trusted global supplier of specialty medications. We ensure Nexataf (Tenofovir Alafenamide) is accessible to patients and healthcare providers worldwide through reliable worldwide shipping. Whether you are located in South Asia, the Middle East, Africa, Europe, or beyond, Mediaid Pharmacy provides fast and reliable delivery with full order support. Contact us directly via WhatsApp, phone, or WeChat for pricing, availability, and delivery enquiries.
Why Choose Nexataf (Tenofovir Alafenamide) from Mediaid Pharmacy?
Nexataf represents a modern, low-dose option for the long-term management of chronic Hepatitis B. As the generic equivalent of Vemlidy by Gilead Sciences, it delivers the same active ingredient, Tenofovir Alafenamide, with the same proven mechanism and improved safety profile relative to older tenofovir formulations, at a dramatically more affordable price. Manufactured by Everest Pharmaceuticals Ltd. under cGMP-compliant standards and distributed globally by Mediaid Pharmacy, Nexataf gives patients worldwide access to effective, ongoing HBV suppression therapy without the financial burden of brand-name alternatives. For patients and physicians seeking a proven, affordable, and accessible Tenofovir Alafenamide option with worldwide delivery, Nexataf from Mediaid Pharmacy is the trusted choice.
Frequently Asked Questions About Nexataf (Tenofovir Alafenamide)
What is Nexataf used for?
Nexataf (Tenofovir Alafenamide) is used for the ongoing treatment of chronic Hepatitis B virus infection in patients aged 6 years and older with compensated liver disease. It works by blocking the enzyme HBV needs to copy its genetic material, suppressing the virus over the long term.
How should I take Nexataf?
Nexataf is taken as one 25mg tablet, once daily, with food. Treatment is usually continued long-term to maintain suppression of the virus. Do not stop taking Nexataf without your physician’s guidance, as stopping treatment can cause a serious flare of hepatitis B.
What strength is Nexataf available in?
Nexataf is available in a 25mg film-coated tablet, supplied in a pack of 30 tablets, which is the standard, fixed dose for chronic HBV treatment. Unlike older tenofovir products dosed at 300mg, Nexataf’s active ingredient (Tenofovir Alafenamide) is effective at this much lower 25mg dose.
Is Nexataf the same as Vemlidy (Tenofovir Alafenamide by Gilead)?
Yes. Nexataf is the generic equivalent of Vemlidy. Both contain the same active ingredient, Tenofovir Alafenamide, at the same 25mg dose. Nexataf is manufactured by Everest Pharmaceuticals Ltd. in Bangladesh and offers the same clinical mechanism as Vemlidy at a significantly lower cost.
What are the side effects of Nexataf?
Common side effects include headache, abdominal pain, fatigue, cough, and nausea. Nexataf carries a boxed warning for lactic acidosis/severe liver enlargement with fat build-up, and for severe flares of hepatitis B if treatment is stopped. Always consult your physician for a complete assessment of your individual risks and benefits before starting treatment.
Can Nexataf be used with other medications?
Nexataf should not be combined with certain seizure medications (oxcarbazepine, phenobarbital, phenytoin), rifamycin antibiotics (rifabutin, rifampin, rifapentine), or St. John’s Wort, as these reduce its effectiveness. Always inform your physician of all medications, supplements, and herbal products you are taking before starting Nexataf, and get tested for HIV-1 before starting.
Is Nexataf safe during pregnancy or breastfeeding?
Please consult your physician before starting treatment if you are pregnant, planning to become pregnant, or breastfeeding, so that the potential risks and benefits can be discussed for your individual situation.
Can I order Nexataf online with worldwide shipping?
Yes. Mediaid Pharmacy supplies Nexataf (Tenofovir Alafenamide) 25mg globally with worldwide shipping. Contact us via WhatsApp, phone, or WeChat at +8801773428128 or email us at info@mediaidpharmacy.com to enquire about pricing, availability, and delivery to your country.
Order Nexataf (Tenofovir Alafenamide) 25mg with Worldwide Shipping
Phone / WhatsApp / WeChat: +8801773428128 | Email: info@mediaidpharmacy.com
