Buy Sofoxen 400 MG (Sofosbuvir) - Mediaid pharmacy

Sofoxen 400 MG (Sofosbuvir)

Product Name : Sofoxen
Generic Name : Sofosbuvir
Formulation : Tablet
Available Pack Size : 28’s
Available Strengths : 400 mg
Registrations : Bangladesh

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Product Information

Sofoxen (Sofosbuvir) 400mg is an oral HCV NS5B polymerase inhibitor, a direct-acting antiviral used as a foundational component of combination therapy for chronic Hepatitis C Virus (HCV) infection. It works by inhibiting the NS5B RNA-dependent RNA polymerase, the enzyme HCV uses to copy its genetic material, halting viral replication. Sofoxen is always used together with other antiviral agents, such as ribavirin, peginterferon alfa, or another direct-acting antiviral, selected according to HCV genotype and treatment history. Manufactured by Everest Pharmaceuticals Ltd., Bangladesh and globally supplied by Mediaid Pharmacy with worldwide shipping.

Basic Product Information of Sofoxen (Sofosbuvir) 400mg

Brand Name	Sofoxen (Sofosbuvir)
Generic Name	Sofosbuvir INN
Drug Class	HCV NS5B Nucleotide Analogue Polymerase Inhibitor (Direct-Acting Antiviral)
Available Strength	400mg
Formulation	Film-Coated Tablet
Pack Size	28 Tablets per Pack
Primary Indication	Chronic Hepatitis C Virus (HCV) Infection, as Part of Combination Antiviral Therapy
Regulatory Approvals	USFDA Approved (Combination Therapy for HCV Genotypes 1-4). EMA Approved. Carries an FDA Boxed Warning for HBV reactivation risk.
Originator Brand	Sovaldi by Gilead Sciences
Manufacturer	Everest Pharmaceuticals Ltd., Dhaka, Bangladesh
Global Supplier	Mediaid Pharmacy, Worldwide Shipping Available
Registration	Registered in Bangladesh
Storage Conditions	Store below 30 degrees Celsius. Keep in a dry place away from light and moisture. Keep out of the reach of children.

How Sofoxen (Sofosbuvir) Works

Sofoxen contains Sofosbuvir, a prodrug that is metabolised inside liver cells to its active triphosphate form. This active form acts as an inhibitor of the HCV NS5B RNA-dependent RNA polymerase, the enzyme the virus depends on to replicate its genetic material. By being incorporated into the growing viral RNA chain and causing chain termination, Sofosbuvir halts HCV replication.

Because HCV can develop resistance quickly if a single antiviral is used alone, Sofoxen is always prescribed as part of a combination regimen, alongside ribavirin, peginterferon alfa, or another direct-acting antiviral with a different mechanism (such as an NS5A or NS3/4A inhibitor). The specific combination and treatment duration depend on the patient’s HCV genotype, prior treatment history, and whether cirrhosis is present.

Sofoxen is taken as a once-daily oral tablet, and forms the backbone of many modern interferon-free and interferon-containing HCV treatment regimens.

Indications for Sofoxen (Sofosbuvir)

Sofoxen (Sofosbuvir) is indicated, as a component of combination antiviral therapy, for the following:

Genotype 1 or 4 Chronic HCV

In combination with peginterferon alfa and ribavirin, for adult patients with chronic HCV genotype 1 or 4 infection.

Genotype 2 or 3 Chronic HCV

In combination with ribavirin alone (an interferon-free regimen), for adult patients with chronic HCV genotype 2 or 3 infection.

HCC Patients Awaiting Liver Transplantation and HCV/HIV-1 Co-Infection

In combination with ribavirin, for patients with hepatocellular carcinoma awaiting liver transplantation to prevent HCV recurrence post-transplant, and for patients with HCV/HIV-1 co-infection, following the same genotype-based combination principles.

Benefits of Sofoxen (Sofosbuvir) 400mg

Foundational DAA Backbone

Sofoxen forms the backbone of many HCV treatment regimens, and can be flexibly combined with ribavirin, peginterferon, or another direct-acting antiviral based on the patient’s specific needs.

Enables Interferon-Free Regimens

For genotype 2 and 3 infection, Sofoxen can be combined with ribavirin alone, avoiding the additional side effects associated with interferon-based therapy.

Convenient Once-Daily Dosing

Sofoxen is taken as a single tablet, once daily, with or without food, simplifying the antiviral component of combination HCV therapy.

Affordable Alternative to Sovaldi

Sofoxen contains the same active ingredient as Sovaldi by Gilead Sciences, at a significantly lower cost, making combination HCV therapy more financially accessible worldwide.

Supports Pre-Transplant Patients

For patients with hepatocellular carcinoma awaiting liver transplantation, Sofoxen combination therapy can help reduce the risk of HCV recurrence after transplant.

cGMP Certified Manufacturing

Produced by Everest Pharmaceuticals Ltd. under cGMP-compliant manufacturing standards, helping ensure consistent quality, purity, and potency in every batch of Sofoxen tablets.

How to Take Sofoxen (Sofosbuvir)

Route: Oral, with or without food. The tablet should be swallowed whole.

Standard dose: One 400mg tablet, taken orally, once daily, always as part of a combination regimen with ribavirin, with or without peginterferon alfa, or another direct-acting antiviral as directed by the prescribing physician.

Treatment duration: Typically 12 to 24 weeks, depending on the specific combination regimen, HCV genotype, prior treatment history, and presence of cirrhosis. Follow your physician’s prescribed course precisely.

Missed dose: If a dose is missed and remembered within 18 hours of the usual time, take it as soon as possible; if more than 18 hours have passed, skip the missed dose and resume the normal schedule the next day.

Hepatic impairment: No dose adjustment is required for mild, moderate, or severe hepatic impairment.

Renal impairment: No dose adjustment is required in mild to moderate renal impairment. Use in severe renal impairment or end-stage renal disease should follow specific physician guidance.

Combination therapy: Sofoxen is not intended to be used as a standalone treatment for HCV. Refer also to the prescribing information for ribavirin, peginterferon alfa, or any other antiviral agent your physician has combined with Sofoxen, as these carry their own dosing requirements and precautions.

Boxed Warning – Prescription Medication. Sofoxen carries a boxed warning for the risk of Hepatitis B Virus (HBV) reactivation in patients co-infected with HCV and HBV, which has led to fulminant hepatitis, liver failure, and death in some cases. All patients must be tested for HBV infection (HBsAg and anti-HBc) before starting Sofoxen, and HBV-coinfected patients require monitoring during and after treatment. Sofoxen must only be prescribed and monitored by a physician experienced in managing HCV therapy, and always used together with the appropriate companion antiviral agent(s).

Monitoring and Dosage Adjustments

Before starting Sofoxen, all patients must be tested for current or prior Hepatitis B virus infection. Monitoring during treatment largely follows the requirements of the companion antiviral agent(s) prescribed alongside Sofoxen; for example, ribavirin requires haemoglobin monitoring, and peginterferon alfa requires monitoring of blood counts and mood/psychiatric symptoms. If Sofoxen is combined with amiodarone, close cardiac monitoring is required due to a risk of serious bradycardia. Report any yellowing of the skin or eyes, unusual fatigue, dizziness, fainting, or a very slow or irregular heartbeat to your doctor immediately.

Drug Interactions and Important Information

Sofoxen should not be used with amiodarone unless no alternative treatment is available, due to a risk of serious symptomatic bradycardia, which has led to fatal cases and the need for a pacemaker when sofosbuvir-containing regimens were combined with amiodarone, particularly alongside beta-blockers or in patients with underlying heart conditions.

Avoid concomitant use of Sofoxen with P-glycoprotein inducers, such as rifampin, St. John’s Wort, and carbamazepine, as these can significantly decrease Sofosbuvir plasma concentrations and reduce effectiveness. Sofoxen must always be combined with the specific companion antiviral agent(s) directed by your physician; do not combine it with any additional antiviral medication that has not been specifically prescribed. Always inform your physician of all medications, supplements, and herbal products you are currently taking before starting Sofoxen.

Side Effects and Precautions

Common Side Effects

Fatigue

Headache

Nausea

Insomnia

Anaemia (more common when combined with ribavirin and peginterferon)

Serious Warnings and Precautions

Hepatitis B virus reactivation in HCV/HBV coinfected patients, potentially fatal. Requires baseline HBV testing.

Serious symptomatic bradycardia when combined with amiodarone, in rare cases fatal.

Additional risks depend heavily on the companion antiviral agent(s) used, particularly ribavirin (significant teratogenic and haemolytic risk) and peginterferon alfa.

Who Should Use Sofoxen (Sofosbuvir)?

Sofoxen is suitable for adult patients with chronic Hepatitis C virus infection, genotypes 1 through 4, being treated as part of a physician-selected combination antiviral regimen, including patients with HCC awaiting liver transplantation and patients with HCV/HIV-1 co-infection. It is prescribed by hepatologists, gastroenterologists, and infectious disease specialists experienced in selecting and managing combination HCV therapy. A thorough medical assessment including HCV genotype testing, HBV testing, and baseline liver function is required before initiating treatment.

Manufacturer: Everest Pharmaceuticals Ltd.

Everest Pharmaceuticals Ltd. is a vertically integrated pharmaceutical company based in Dhaka, Bangladesh, focused on complex, technology-driven specialty medicines across oncology, nephrology, and virology. Operating under Bangladesh’s TRIPS/Doha Declaration exemption for least-developed countries, Everest manufactures advanced generics such as Sofoxen under cGMP-compliant standards, with the stated mission of making high-cost, life-saving medicines accessible and affordable to patients around the world. Sofoxen is one of Everest’s specialty virology products, offering a bioequivalent alternative to Sovaldi by Gilead Sciences at a fraction of the cost.

Global Supplier: Mediaid Pharmacy with Worldwide Shipping

Mediaid Pharmacy is a trusted global supplier of specialty medications. We ensure Sofoxen (Sofosbuvir) is accessible to patients and healthcare providers worldwide through reliable worldwide shipping. Whether you are located in South Asia, the Middle East, Africa, Europe, or beyond, Mediaid Pharmacy provides fast and reliable delivery with full order support. Contact us directly via WhatsApp, phone, or WeChat for pricing, availability, and delivery enquiries.

Why Choose Sofoxen (Sofosbuvir) from Mediaid Pharmacy?

Sofoxen represents the antiviral backbone of many effective Hepatitis C treatment regimens. As the generic equivalent of Sovaldi by Gilead Sciences, it delivers the same active ingredient, Sofosbuvir, with the same proven NS5B polymerase inhibition mechanism at a dramatically more affordable price. Manufactured by Everest Pharmaceuticals Ltd. under cGMP-compliant standards and distributed globally by Mediaid Pharmacy, Sofoxen gives patients worldwide access to essential combination HCV therapy without the financial burden of brand-name alternatives. For patients and physicians seeking a proven, affordable, and accessible Sofosbuvir option with worldwide delivery, Sofoxen from Mediaid Pharmacy is the trusted choice.

Frequently Asked Questions About Sofoxen (Sofosbuvir)

What is Sofoxen used for?

Sofoxen (Sofosbuvir) is used, always as part of a combination regimen, to treat chronic Hepatitis C virus infection across genotypes 1 through 4. Depending on genotype, it is combined with ribavirin, peginterferon alfa and ribavirin, or another direct-acting antiviral, and works by blocking the enzyme HCV uses to copy its genetic material.

How should I take Sofoxen?

Sofoxen is taken as one 400mg tablet, once daily, with or without food, always alongside the specific companion antiviral medication(s) prescribed by your physician. Treatment typically lasts 12 to 24 weeks. Never take Sofoxen alone without the prescribed combination therapy, and complete the full course even if you feel well.

What strength is Sofoxen available in?

Sofoxen is available in a 400mg film-coated tablet, supplied in a pack of 28 tablets, enough for a standard 4-week supply at the once-daily dose.

Is Sofoxen the same as Sovaldi (Sofosbuvir by Gilead)?

Yes. Sofoxen is the generic equivalent of Sovaldi. Both contain the same active ingredient, Sofosbuvir, and work through the same NS5B polymerase inhibition mechanism. Sofoxen is manufactured by Everest Pharmaceuticals Ltd. in Bangladesh and delivers the same clinical mechanism as Sovaldi at a significantly lower cost.

What are the side effects of Sofoxen?

Common side effects include fatigue, headache, nausea, and insomnia, with anaemia more likely when Sofoxen is combined with ribavirin and peginterferon. The most important risks are Hepatitis B virus reactivation in patients also infected with HBV, and serious slow heart rate if combined with amiodarone. Always consult your physician for a complete assessment of your individual risks and benefits before starting treatment.

Can Sofoxen be used with other medications?

Sofoxen must always be used with a specific companion antiviral agent prescribed by your physician, and should not be combined with amiodarone unless no other option is available. Avoid strong P-glycoprotein-inducing medications such as rifampin, St. John’s Wort, and carbamazepine, as these reduce effectiveness. Always inform your physician of all medications, supplements, and herbal products you are taking before starting Sofoxen.

Is Sofoxen safe during pregnancy or breastfeeding?

Please consult your physician before starting treatment if you are pregnant, planning to become pregnant, or breastfeeding. This is especially important if ribavirin is part of your regimen, as ribavirin carries significant pregnancy-related restrictions for both patients and their partners.

Can I order Sofoxen online with worldwide shipping?

Yes. Mediaid Pharmacy supplies Sofoxen (Sofosbuvir) globally with worldwide shipping. Contact us via WhatsApp, phone, or WeChat at +8801773428128 or email us at info@mediaidpharmacy.com to enquire about pricing, availability, and delivery to your country.

Order Sofoxen (Sofosbuvir) 400mg with Worldwide Shipping

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